What is semaglutide? Pros and Cons –

Semaglutide is a drug that is primarily prescribed by healthcare professionals to treat people with type 2 diabetes, help some people lose weight, and reduce the risk of serious heart problems such as heart attack or stroke

(*. )The drug belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists, which mimic the effects of the naturally occurring glucagon-like peptide-1 (GLP-1) receptor hormone. In short, it is a synthetic form of GLP-1.

Currently there are only three medications that contain active semaglutide: Ozempic, Wegovy, and Rybelsus.

The first drug,

Ozempic , was developed by Novo Nordisk and approved by the U.S. Food and Drug Administration (FDA) in 2017. It is an injectable medication approved to treat type 2 diabetes.

Rybelsus is the second semaglutide drug developed and approved in 2019 for the treatment of type 2 diabetes. Unlike Ozempic, it is the first oral GLP-1 receptor agonist used for this purpose.

In 2021, the U.S. Food and Drug Administration (FDA) approved Wegovy, a more potent form of semaglutide. This drug is specifically indicated for

weight loss – it can help people who are overweight or have weight-related health problems lose weight. Like the other two forms of semaglutide, it needs to be used in conjunction with a healthy diet and regular exercise.  


How the hormone GLP-1 works

Semaglutide works by stimulating the release of the hormone insulin. When taken, especially after a meal when blood sugar may be high, semaglutide causes the body to release more insulin. The released insulin lowers blood sugar levels by helping glucose enter cells, where it can be used as energy or stored as fat for later use.  

In addition to regulating insulin production, semaglutide blocks the pancreas from releasing the hormone glucagon, which increases blood sugar levels by allowing the

liver to release stored glucose into the blood. This helps lower blood sugar levels and improve blood sugar control in people with type 2 diabetes.  

When semaglutide is released into the blood, it also slows the absorption of nutrients from the digestive tract into the bloodstream, slowing the rate at which food leaves the stomach.


Slower stomach emptying can make you feel fuller longer and reduce your appetite. This can prevent overeating, leading to

weight loss .  

In addition, semaglutide interacts with the GLP-1 receptor in the brain, regulating appetite and satiety.


(* ) 

Here are three key benefits of semaglutide.

1. Promote

Weight Loss

When combined with a healthy lifestyle, such as a healthy diet and exercise, semaglutide is the most effective drug for

weight loss

. First, semaglutide mimics the effects of the natural hormone GLP-1, which plays an important role in appetite control. Once ingested, it stimulates the pancreas to release insulin, which is essential for transporting glucose from the blood into cells. By promoting the entry of glucose into cells, semaglutide helps regulate blood sugar, thereby reducing the likelihood of sudden energy fluctuations that trigger cravings for high-calorie foods and lead to

weight loss



*)Semaglutide also activates GLP-1 receptors in the brain, increasing satiety and reducing overall food intake. The reduction in appetite helps patients eat fewer calories, which over time contributes to weight loss .

It also slows gastric emptying, the process by which food leaves the stomach and enters the small intestine. This slower emptying rate helps prolong feelings of fullness after a meal, which further helps control appetite.

Through these combined effects, semaglutide may effectively support weight loss by making people feel fuller for longer, reducing food cravings and promoting healthier eating habits.

Researchers showed that semaglutide is effective for weight loss in a study of more than 300 participants. 78% were women, the average age was 47,106 kg, and the average body mass index was 38.5 kg/m2.

The study examined the effectiveness of semaglutide using two different approaches. The “treatment guideline” estimate approach examined the effects of semaglutide on each study participant, regardless of whether they stopped taking the medication or received other weight loss interventions. The second strategy, a so-called “test product,” evaluated the effectiveness of semaglutide when taken as a prescription. Participants received 2.4 mg of semaglutide injected subcutaneously once weekly compared to placebo.

Semaglutide resulted in significantly greater weight loss at 104 weeks compared to placebo, based on estimates from treatment guidelines. Patients taking semaglutide lost an average of 15% and 2% of their baseline body weight, while those taking placebo lost 2.6%. In addition, people taking semaglutide were more likely to lose at least 5% of their body weight.

However, you should note that higher doses of semaglutide may produce greater weight loss than lower doses of Rybelsus or Ozempic.

2. Improved blood sugar control

When blood sugar levels rise, semaglutide stimulates the pancreas to secrete insulin and reduces the amount of glucose produced by the liver . This dual action helps maintain stable blood sugar levels.

Stable blood sugar levels are critical for bodybuilders because they help maintain consistent energy levels during training and recovery. Blood sugar fluctuations can lead to a drop in energy, which can affect performance and endurance.

3. Improves cardiovascular health

Semaglutide has been shown to provide benefits to the cardiovascular system. Clinical studies show that it can reduce the risk of serious cardiovascular events such as heart attack and stroke, especially in people with type 2 diabetes who are at high risk for these diseases. It can improve lipid profiles, reduce inflammation and improve systolic and diastolic blood pressure. It can also reduce fasting blood sugar and glycated hemoglobin, thereby reducing the risk of cardiovascular disease, heart attack and stroke.


Cardiovascular health is vital to bodybuilders because a strong and efficient heart cycle is essential for optimal performance and recovery. Improved cardiovascular health means greater endurance during training, more efficient delivery of nutrients to the muscles, and faster recovery times . All of which help bodybuilders stay in peak physical shape.



Originally developed to treat type 2 diabetes, semaglutide has been approved by the FDA under the trade name Wegovy for weight loss . Since its approval, it has demonstrated remarkable effectiveness in promoting weight loss , making it a valuable treatment option for individuals battling obesity and related health issues.


When administered as Ozempic or Rybelsus, its purpose becomes treating type 2 and reducing the risk of serious cardiovascular events such as heart attack, stroke, or death.



Like any medication, semaglutide can cause side effects. Common side effects include:

1. Nausea and vomiting


Nausea is one of the most common side effects of the drug semaglutide. According to studies,about 20%of people who take it to treat type 2 diabetes experience nausea. Vomiting can also occur, but it is not as severe as nausea.


For bodybuilders, nausea can disrupt mealtimes and nutrient absorption, and affectmuscle recoveryand muscle growth. On the other hand, vomiting can lead to dehydration and electrolyte imbalance, which is a key issue for bodybuilders because it affects performance and recovery.


If you take a high dose of semaglutide, which is theweight loss version, nausea is likely to occur. Higher doses slow stomach emptying, which can cause discomfort because the stomach stays fuller for longer, leading to vomiting.

To minimize this, it may also help to start with a lower dose and then gradually increase it. It may also help to eat smaller, more frequent meals, rather than larger ones.

2. Diarrhea


Diarrhea is also a common side effect of semaglutide. It occurs in 9% of people who take the drug for type 2 diabetes and in 30% of people who take it. This is Weight losstaking it. Symptoms occur as the gastrointestinal tract adjusts to higher doses of semaglutide. Dehydration and nutrient loss can occur if not treated properly.

Diarrhea can be prevented by drinking enough fluidsand avoiding foods that irritate the stomach, such as high-fat and spicy foods. Your doctor should also gradually increase your dose over time.

3. Constipation


Constipation may occur, but it is less common than diarrhea. This is because semaglutide slows stomach motility, which weakens over time.

However, if constipation persists for a long time, you should adjust your schedule, such as: B.Eat enough fiber and drink plenty of water. Regular physical activity can also promote bowel movements.

4. Abdominal pain

Abdominal pain may be caused by the gastrointestinal effects of semaglutide, such as: B. Slowing stomach emptying and increasing feelings of fullness. Gradually increasing the dose and changing the diet, such as: Other measures, such as avoiding large meals and high-fat foods, may relieve this pain. If the pain persists, contact your doctor immediately

5. Headache

Semaglutide does not directly cause headaches, but there are some specific side effects of semaglutide, such as: B. Headaches can occur as a result of changes in blood sugar levels or dehydration.


Maintaining adequate hydration and stable blood sugar levels through regular, balanced intake To minimize this, it is important to eat at least 12 meals at regular intervals.


6. Fatigue

Fatigue may be caused by the body’s adjustment to new blood sugar levels and general metabolic changes caused by semaglutide. This is primarily a side effect of Wegovy, and in clinical trials, it occurred in 11% of people taking it. Less than 5% of people taking Ozempic also experienced fatigue.  


sleep , proper nutrition, and gradual dose increases can help relieve fatigue. It is also important to monitor blood sugar levels and adjust your diet to maintain energy levels throughout the day.  7. Thyroid tumors


In rodent studies, semaglutide was associated with an increased risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)

. This risk has not been definitively elucidated in humans but is considered a potential problem. The exact mechanism is unclear but may be due to long-term activation of the GLP-1 receptor in the thyroid gland.

 Individuals with a personal or family history of MTC or multiple endocrine neoplasia syndrome type 2 (MEN 2) should avoid semaglutide. It is also important to regularly monitor thyroid function and symptoms, such as: B. Swelling of the throat or difficulty swallowing.  

8. Allergic Reactions


Allergic reactions to semaglutide can range from a mild rash to severe anaphylaxis. These occur because the immune system mistakenly identifies the drug as harmful and triggers an allergic reaction.


Before starting semaglutide, you should tell your doctor about any known allergies. Antihistamines can help relieve mild allergic reactions. If a severe reaction occurs, seek medical attention immediately and stop the medication.

9. Kidney damage


Although studies have shown that semaglutide has benefits for the kidneys in people with type 2 diabetes, semaglutide can still cause dehydration, especially due to gastrointestinal side effects such as vomiting and diarrhea. Dehydration reduces blood flow to the kidneys and can lead to acute kidney injury (AKI).


However, kidney damage occurs mainly in people who already have kidney problems or who take diuretics to eliminate excess water.

Adequate fluid intake and control of gastrointestinal side effects can help prevent dehydration. Regular monitoring of kidney function with blood tests is recommended.

10. Hair loss


Hair loss is a less common side effect that may be indirectly related to the effects of semaglutide on changes in nutrient absorption and metabolism. Significant

weight loss

and dietary changes can also cause hair loss.

 This side effect most commonly affects patients taking the Ozembic or Wegov versions of semaglutide. Studies

have shown that hair loss occurs in about 3% of patients taking these medications.  

 Adequate nutrition, including adequate intake of vitamins and minerals, can help reduce hair loss. Biotin supplements and proper hair care can also help.  




Semaglutide offers a variety of benefits that may be beneficial to bodybuilders, including improved blood sugar control, enhanced

weight loss

, cardiovascular health benefits, and improved insulin sensitivity. These effects support overall health and contribute to better performance, endurance, and body composition, making semaglutide a valuable addition to your treatment routine under proper medical guidance.

Although semaglutide offers significant benefits in weight loss

and blood sugar control, it may cause a variety of side effects, including diarrhea, vomiting, constipation, kidney damage, and fatigue.

To minimize most of semaglutide’s side effects and maximize its benefits, gradually increasing your dose, changing your diet, and consuming adequate fluids are recommended. Also, be sure to consult your doctor to tailor these strategies to your needs and ensure safe and effective use of the medication.

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